How p53 mutations drive immunotherapy resistance—and a path to overcome it

Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from ...
News-Medical.Net

Study reveals how p53 mutations cause tumors to resist cancer immunotherapy

Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from ...
Discover Magazine

Two Children With a Rare Epilepsy Mutation Show Improvement After Personalized Genetic Treatment

Learn how personalized genetic therapy helped researchers treat two children with a rare form of epilepsy, enabling one to ...

Three genetic modifiers may alter inherited Alzheimer's onset and progression

Autosomal dominant Alzheimer's disease (ADAD) is a genetically inherited form of Alzheimer's disease that accounts for only ...
Labroots

High-Altitude Gene Mutation May Aid Nerve Damage Repair

Scientists have identified a genetic mutation that helps protect the brain function of animals that live in high-altitude, low-oxygen environments. This mutation has provided new insights into how ...

Personalized gene therapy helps teen with rare form of severe epilepsy walk independently

SCN2A-related developmental epileptic encephalopathy (DEE) is a rare, severe form of childhood epilepsy and one of the most ...
Labroots

Mutation Hotspots in the Human Genome are Discovered

Scientists have revealed parts of the genome that are especially vulnerable to mutations that occur very early on in development. These areas are in the initial portions of genes, where the cell tends ...