The path from target to drug is not a direct one; many complex uncertainties, from the basic biological to the clinical physiological level, exist 1. Successful therapeutics have often been identified ...

Understanding how cells process nutrients and produce energy - collectively known as metabolism - is essential in biology. However, analyzing the vast amounts of data on cellular processes to ...

In the context of cell signaling, kinetic proofreading was introduced to explain how cells can discriminate among ligands based on a kinetic parameter, the ligand-receptor dissociation rate constant.

A new concept of kinetic modules in biochemical networks could revolutionize the understanding of how these networks function. Scientists from the University of Potsdam and the Max Planck Institute of ...

Chemical-kinetic modelling is the key to understanding and simulating reactive combustion processes. Our aim is to develop, optimise and provide accurate and efficient models for CFD that are directly ...

A simple first-order kinetic model of hydrocracking reactions using pseudocomponents closes the gap between the process and a model of the separation and reaction network. The model delivers good ...