In the earliest stages of life, mammalian embryos start as a disorganized cluster of cells. As development progresses, these cells become organized into well-defined shapes and structures. This ...

Getting it over the finish line was a labor of love—and now, more than five years after her death, the lab of former Sloan ...

Using CRISPR-based engineering methods to prompt stem cells to organize into embryo-like structures, scientists were able to create 'programmable' cellular models of embryos without ever experimenting ...

Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns. To advance ...

Researchers led by developmental biologist Kathy Niakan at the University of Cambridge have used base editing in human embryos to learn more about human embryonic development. By deactivating a gene ...

In the earliest hours after fertilization, an embryo takes its first steps toward becoming a living organism by shedding maternal control and activating its own genetic program. This critical process, ...

In order for vertebrate embryos to develop their body axes, they require what is known as an embryonic signaling center. This group of cells provides the instructions that determine where up and down, ...

Embryonic development, also known as embryogenesis, is a cornerstone in understanding the origins of life. But studying this marvel of intricate and layered biological processes in people faces ...

When Berna Sozen, PhD, assistant professor of Developmental Stem Cell Biology at Yale, was in her first weeks of pregnancy, she couldn’t help but wonder about what exactly was going on in the “black ...

"Guinea pigs can become a valuable model for understanding how early disturbances in embryonic development can affect health later in life. Since guinea pig development mirrors that of humans better ...