A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

There are two types of Tph cells in rheumatoid arthritis joints that have different roles. Stem-like Tph cells live inside immune “hubs” called tertiary lymphoid structures, where they interact ...

Immune effector cell-associated neurotoxicity syndrome (ICANS) is a possible side effect of certain immunotherapies. This condition causes inflammation in the brain, leading to symptoms. ICANS is a ...

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8 + T cell division for the generation of memory precursor cells. CD8 + T ...

Hiroshima University researchers have demonstrated a proof of concept for the mass production of genome-edited T cells that ...

A substantial proportion of patients with autoimmune diseases experienced a new side effect called local immune effector cell–associated toxicity syndromes (LICATS) after receiving chimeric antigen ...

A pair of studies examining immune response in C. elegans reveal broad implications for understanding pathogen detection in higher animals and the evolutionary origins of immunity itself. The research ...

An open-label, phase I trial of the SIRPα monoclonal antibody, BI 770371, alone and in combination with the PD-1 inhibitor ezabenlimab in patients with advanced solid tumors. This is an ASCO Meeting ...